🧬 When immunotherapy produces a complete response, should surgery still be automatic?
@OncoAlert
At #ESMO26, the first interim analysis of the phase II GERCOR-GONO DEWI study explores one of the most provocative organ-preservation strategies in localized dMMR/MSI-H gastroesophageal adenocarcinoma:
dostarlimab + watch-and-wait.
📊 24 evaluable patients
➡️ 1-year cCR: 62.5% (15/24)
➡️ No relapse or death among patients with 1-year cCR at a median follow-up of 16.2 months
➡️ Grade 3–4 dostarlimab-related AEs: 21%
➡️ 9 patients underwent surgery — all achieved R0 resection
🎯 Why this matters: this is not just an immunotherapy efficacy story. It is a potential shift in treatment philosophy.
For selected dMMR/MSI-H patients, the future may move from “treat, then operate” toward “treat, assess deeply, and preserve the organ when oncologically safe.”
The key challenge now is defining how confidently we can identify true complete responders and how durable that response remains over time.
A fascinating step toward biomarker-driven organ preservation.
@CathyEngMD @BenWestphalen @graokane @NiuSanford @GillSharlene @pashtoonkasi @DrVilmaPBarcia @GIMedOnc @DaisukeKotani @KoheiShitara
#OncoAlert #ESMO26 #GICancer #MSIHigh #dMMR #Immunotherapy #OrganPreservation
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Watch-and-wait (W&W) strategy for dostarlimab in localized deficient dMMR/MSI-H gastroesophageal adenocarcinoma (GEA): Results from the first interim analysis of the GERCOR-GONO DEWI phase II study
https://esmocongress.esmo.orgOncoAlert 4Sight Abstracts to be Presented at #ESMO26 Watch-and-Wait Strategy for Dostarlimab in Localized dMMR/MSI-H Gastroesophageal Adenocarcinoma: Results From the First Interim Analysis of the GERCOR-GONO DEWI Phase II Study 🔬 Phase II, first interim analysis (24 evaluable patients): dostarlimab with a watch-and-wait strategy in localized dMMR/MSI-H gastroesophageal adenocarcinoma. Primary endpoint: 1-year cCR without surgery. ➡️ 1-year cCR: 62.5% (15/24) ➡️ No relapse or death in patients with 1-year cCR (median follow-up 16.20 mo) ➡️ Grade 3–4 dostarlimab-related AEs: 21%; 9/24 underwent surgery, all R0 ✅ dostarlimab led to a 62.5% 1-year cCR at the first interim analysis, enabling organ preservation. 🎙️ Thierry André 👥 Christelle de la Fouchardière (4Sight Made from Abstracts publicly available at the ESMO website) @CathyEngMD, @BenWestphalen, @graokane, @NiuSanford, , @GillSharlene, @pashtoonkasi, @DrVilmaPBarcia, @Erman_Akkus, @GIMedOnc, @UOzkerim, @MarioBalsaMD, @p_ciracimd, @DraMartinezLago, @DaisukeKotani, @Aiims1742, @ARosen380, @realbowtiedoc, @KoheiShitara,在 X 查看被引用的帖子
来源：Dra. María Natalia Gandur Quiroga · x.com