Cell· Kalil G. Abdullah, Kenji Miki, Charles K. Edgar, Shuangcheng Alivia Wu, Yi Xiao, Yuan-Tai Huang, Richard Drexler, Saritha Krishna, Vinesh T. Puliyappadamba, Li Wei Rachel Tay, Fanen Yuan, Milan R. Savani, Maged T. Ghoche, Shawn E. Kotermanski, Jeffrey I. Traylor, Lei Guo, Kathryn Gunn, William H. Hicks, Diana D. Shi, Belgin Yalçın, Kim Kilian, Min Tang, Mitchell Moyer, Michael M. Levitt, Mohamad El-Shami, Skyler Oken, Namya Manoj, Lauren C. Gattie, Bailey C. Smith, Pranita Kaphle, Tracey Shipman, Raymond E. West, Chaoying Liang, Yasmina Eshac, Tzu-Yi Chia, Toral R. Patel, Kimmo J. Hatanpaa, Prithvi Raj, Jason M. Miska, Denise M.O. Ramirez, Shang Ma, Thomas D. Nolin, Bradley C. Lega, Pascal O. Zinn, Bianca J. Kuhn, Natalie M. Clark, C. Williams, D.R. Mani, Michael A. Gillette, Marco A. Calzado, Lin Xu, Lauren G. Zacharias, Feng Cai, Alexander Ksendzovsky, Thomas P. Mathews, Julie-Aurore Losman, Benjamin Levi, Tara Barron, Jay R. Gibson, Timothy E. Richardson, Osaama H. Khan, Sameer Agnihotri, Shawn L. Hervey-Jumper, Simon Chamberland, Michelle Monje, Kimberly M. Huber, Ralph J. DeBerardinis, Samuel K. McBrayer·· 17 天前精选评分57
胶质瘤通过产生胍基乙酸代谢物驱动神经元活动与肿瘤生长
Gliomas phenocopy an inborn error of metabolism to drive neuronal activity and tumor growth
导读
胶质瘤来源的胍基乙酸（GAA）通过GABAA受体使邻近神经元去极化，消耗该代谢物可降低神经元活动和胶质瘤生长。
推荐理由
研究发现胶质瘤通过代谢物GAA影响神经元活动并促进自身生长，为靶向肿瘤微环境代谢互作提供了新视角。
来源：Cell · cell.com