G-HOPE-001 🇨🇳 & 🇯🇵 randomised 408 pts in the 3L+ CLDN18.2+ve G/GOJ setting!!

81% Gastric primary & 44% prev resected primary. ORR 37% vs 8% (IA2). PFS at IA1 5 vs 2 mo, HR 0.47. Toxicity seems similar to alternative tx.

Impressive collaboration.

#ESMO26 @OncoAlert @myESMO