对 #melanoma 癌症患者来说是个好消息:根据在今年马德里举行的 #ESMO26 会议上展示的研究,一种旨在防止手术后黑色素瘤复发的个性化 #cancervaccine 新结果显示了积极成果。
研究发现,将专门定制的癌症疫苗添加到标准免疫治疗中,与单独使用标准免疫治疗相比,成功将黑色素瘤复发的风险降低了 42%。
“这种治疗的思路是,通过专门增强患者的免疫系统以识别其自身的肿瘤细胞,我们可以降低癌症复发的风险,”MSK 黑色素瘤服务主任 Michael Postow 博士表示。“即使在 CT 或 PET 扫描上看不到任何癌症,我们也知道它往往仍然存在——因为如此高比例的患者最终会出现癌症复发。这就是为什么对这种治疗有巨大需求。”
了解更多关于试验中接受治疗的三位 MSK 患者之一的信息:https://bit.ly/3W0Voj2
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STARBOARD phase 3: A randomized, double-blind study of first-line (1L) encorafenib (enco), binimetinib (bini), and pembrolizumab (pembro) vs placebo (pbo) and pembro for unresectable locally advanced or metastatic BRAF V600-mutant melanoma
https://esmocongress.esmo.orgEfficacy and safety of lifileucel and pembrolizumab in patients with immune check point inhibitor-naïve advanced melanoma: Final results from IOV-COM-202 study
https://esmocongress.esmo.orgTranscriptomic and epigenomic profiling of TIL products identifies determinants of clinical benefit in advanced melanoma
https://esmocongress.esmo.orgEmotional distress (ED) upfront neoadjuvant ipilimumab + nivolumab (IPI+NIVO) is associated with lower pathological response and toxicity
https://esmocongress.esmo.orgImpact of BRAF V600K mutation in patients with resectable stage III melanoma: A subgroup analysis of the NADINA trial
https://esmocongress.esmo.orgINTerpath-001: Phase 3 study of the mRNA-based individualized neoantigen therapy (INT) intismeran autogene (intismeran) plus pembrolizumab (pembro) vs pembro alone for adjuvant treatment of resected stage IIB-IV melanoma (MEL)
https://esmocongress.esmo.org来源:Memorial Sloan Kettering Cancer Center · x.com
