🧬 When a treatment works across multiple biomarker-defined subgroups, that can be just as informative as finding one “perfect” predictive marker.
@OncoAlert
At #ESMO26, exploratory ctDNA analyses from phase III evERA Breast Cancer suggest that giredestrant + everolimus maintains PFS benefit across a range of biologically challenging post-CDK4/6i ER+/HER2− advanced #BreastCancer subgroups.
📊 Among 365 ctDNA-evaluable patients:
🔹 cTF ≥1%: PFS HR 0.52
🔹 cTF <1%: HR 0.61
🔹 ESR1 D538: HR 0.58
🔹 ESR1 Y537: HR 0.35
🔹 TP53-mutated: HR 0.65
🔹 PIK3CA-mutated: HR 0.55
🎯 Why this matters: the benefit appears to persist despite differences in ctDNA burden, ESR1 variants, and poor-prognostic molecular features.
For me, the key question now is whether these biomarkers are mainly telling us who is higher risk — or whether future analyses can identify who derives the greatest absolute benefit from this strategy.
Excellent work presented by @stolaney1 and the evERA investigators.
Pinging @matteolambe @aftimosp @E_de_Azambuja @DrSGraff @ErikaHamilton9 @hoperugo @stolaney1 @BianchiniGP @kevinpunie @ElisaAgostinett
#OncoAlert #ESMO26 #BreastCancer #ESR1 #ctDNA #PrecisionOncology
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https://esmocongress.esmo.orgOncoAlert 4Sight Abstracts to be Presented at #ESMO26 Retrospective Exploratory Biomarker Analyses From evERA Breast Cancer: A Phase III Trial of Giredestrant + Everolimus in Patients With Oestrogen Receptor-Positive, HER2-Negative Advanced Breast Cancer in the Post-CDK4/6 Inhibitor Setting 🎙️ Sara Tolaney @stolaney1 🔬 Exploratory biomarker analysis of phase III evERA (365 ctDNA-evaluable): giredestrant + everolimus vs SOC endocrine therapy + everolimus in post-CDK4/6i ER+, HER2– aBC. ➡️ PFS HR 0.52 (0.39–0.70) with cTF ≥1%; 0.61 (0.40–0.94) with cTF <1% ➡️ ESR1m: PFS HR 0.58 (D538) and 0.35 (Y537) ➡️ TP53m PFS HR 0.65 (0.45–0.93); PIK3CAm 0.55 (0.36–0.83) ✅ Giredestrant + everolimus maintained greater PFS benefit regardless of cTF status, with benefit across all ESR1 variants and poor prognostic subgroups. #BreastCancer (4Sight Made from Abstracts publicly available at the ESMO website) Pinging OncoAlert Breast Cancer Faculty @matteolambe @aftimosp @E_de_Azambuja @DrSGraff @ErikaHamilton9 @hoperugo @stolaney1 @BianchiniGP @aftimosp @kevinpunie @ElisaAgostinett @to_be_elizabeth @GaiaGriguolo @JankovicK @raalbany @JavierCortesMD @JaniceTNBCmets @Prof_Nadia_H @LoiSher @jamecancerdoc @Lucarecco @Dr_Oncologista @guiandri76在 X 查看被引用的帖子
来源：Dra. María Natalia Gandur Quiroga · x.com