#Cancer biologist Mitchell Fane studies how aging shapes cancer metastasis and dormancy. His lab at

返回会议原文

返回会议

Emily Storz· @EmilyFCCC · X·2026-04-19 00:23· 2026-04-19评分60

#MELANOMA

解读

免疫治疗前沿 — CAR-T 实体瘤、mRNA 疫苗、TCR-T

mRNA-4157 · 黑色素瘤无复发生存 HR 0.44

正文 · 原文

#Cancer biologist Mitchell Fane studies how aging shapes cancer metastasis and dormancy. His lab at
@FoxChaseCancer
Center uses aged mouse models to better reflect real‑world cancer biology—and improve clinical translation #Melanoma #AACR26

热度 2 · 1 赞 · 0 回复 · 1 转发

会议摘要

1554按药名 irinotecan 对上

Combining an optimized irinotecan formulation with self-amplyfing RNA to treat an immunosuppressive lung metastasis melanoma model

XuXin Sun, Nasim Sarrami, Irafasha C. Casmil, Sijie Zhang, Marcel B. Bally, Anna K. Blakney

读摘要原文 →

4617按代号 NRX-0305 对上

NRX-0305, an orally bioavailable, CNS penetrant pan-mutant BRAF degrader demonstrates robust efficacy in intracranial models of melanoma brain metastasis and primary glioma

Alexandra Borodovsky, Ya-Wen Lu, Ge Peng, Karthik Arumugam, Paul L. Auger, Delia Bradford, Lilly G. Carlson, Scott K. Kimura, Daniel Medina-Cleghorn, Mariah J. Mesner, Davorka Messmer, Madeleine P. Nemchek, Ryan B. Rountree, Rusha M. Sardhara, Sangita Sridharan, Jennifer M. Stokes, Leslie Tong, Alexandra M. Trotier, Jennifer S. Tung, Ge Wei, Jeffrey Wu, Jordan Ye, Gwenn M. Hansen

读摘要原文 →

CT238NCT02706353按药名 sotigalimab 对上

Intratumoral sotigalimab with pembrolizumab induces rapid activation of antigen presenting cells and drives anti-tumor responses in non-injected tumors in metastatic melanoma: A phase I/II study

Salah-Eddine Bentebibel, Daniel J McGrail, Veena Kochat, Emre Arslan, Reham Abdel-Wahab, Sung-Nam Cho, Xiaodong Yang, Daniel H Johnson, Rodabe N Amaria, Isabella C Glitza, Patrick Hwu, Hussein A Tawbi, Jared K Burks, Michael A Davies, Kunal Rai, Suhendan Ekmekcioglu, Adi Diab

读摘要原文 →

来源：Emily Storz · x.com