#AACR26 In MATISSE, need to acknowledge the heterogeneity and going forward, should we distinguish N2 vs non-N2? pCR rates of IPH5201 + d...

AACR 2026 现场信号· @ · X·2026-04-22 20:25· 2026-04-22评分60

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#AACR26 在 MATISSE 中，需要认识到异质性；展望未来，是否应区分 N2 与非 N2？IPH5201 + durva/化疗的 pCR 率令人鼓舞，尤其是在 PDL1 高表达时；与现有治疗选择相比差距不大，但样本量较小，且为单臂研究。https://t.co/It24B5NNZC

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会议摘要

CT231NCT05742607按代号 IPH5201 对上

Dual CD39 and PD-L1 inhibition: Interim results from the phase 2 MATISSE trial of IPH5201 plus durvalumab (durva) and platinum-based chemotherapy (CT) in patients (pts) with resectable NSCLC

Fabrice Barlesi, Tibor Csoszi, Renata Duchnowska, Thomas Egenod, Laurent Greillier, Amanda Psyrri, Maurice Perol, Herve Lena, Agnes Boyer-Chammard, Veronia Todary, Julien Viotti, Pascale André, Carine Paturel, Markus Jensen

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来源：AACR 2026 现场信号 · x.com