Science Translational Medicine· Changshun Han, Chengyong He, Weiping Hu, Zhiyuan Chen, Xiaoyan Ding, Lingxiao Ye, Sihao Zhu, Lin Zhong, Shuni Zhuang, Tianyun Peng, Zixuan Li, Pan He, Lirong Lin, Yingyi Ren, Fengkai Ruan, Zizhen Wang, Yan Zhang, Fucong Zhang, Yitao Guo, Chunyan Yang, Baoding Zhang, Wei Wang, Changgui Li, Bo Wang, Jian Li, Chensong Zhang, Xianming Deng, Zhenghong Zuo·· 9 天前精选评分49
鸟嘌呤核苷酸交换因子 Rin-like 是人和小鼠肾脏尿酸排泄的抑制因子
The guanine nucleotide exchange factor Rin-like is a repressor for renal uric acid excretion in human and mouse
导读
研究发现鸟嘌呤核苷酸交换因子 Rin-like 在人和小鼠中均能抑制肾脏的尿酸排泄。该研究揭示了 Rin-like 通过调控相关转运蛋白功能来影响尿酸稳态的新机制。这一发现为高尿酸血症及相关疾病的治疗提供了潜在的新靶点。
来源：Science Translational Medicine · science.org