PREDICT-HER 的数据非常有趣
基线 ¹⁸F-HER2 PET 可能有助于识别不太可能对 T-DXd 产生应答的患者
• 应答的 NPV:88%(HER2-low/zero 中为 100%)
• 中位 PFS:HER2-PET 阴性患者为 5.1 个月,HER2-PET 阳性患者为 13.6 个月
@OncoAlert #ESMO2026
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Early clinical antitumor activity of VRN101099 across diverse HER2-mutants in solid tumors
https://esmocongress.esmo.orgHealth-related quality of life from HER2CLIMB-05: A phase 3 study of tucatinib versus placebo in combination with trastuzumab and pertuzumab as 1L maintenance therapy for HER2+ mBC
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https://esmocongress.esmo.orgA global, interventional, open-label trial of trastuzumab deruxtecan (T-DXd)–based therapy in first-line HER2-positive metastatic breast cancer: DESTINY-Breast Guide
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https://esmocongress.esmo.org来源:Guilherme Nader Marta · x.com
