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New 6-year results from the phase 3 NATALEE trial show sustained benefit with adjuvant ribociclib + NSAI in patients with high-risk stage II/III HR+/HER2− early breast cancer.
At 6 years, ribociclib + NSAI showed an overall survival benefit compared with NSAI alone, with an absolute difference of 2.1% (91.86% vs 89.73%). The absolute iDFS benefit also increased to 5.3% (83.23% vs 77.92%).
Importantly, these benefits were maintained after patients had been off ribociclib for a median of approximately 3 years, with no new safety signals observed.
Encouraging long-term results from NATALEE.
https://www.annalsofoncology.org/article/S0923-7534(26)08640-0/fulltext
#ESMO26 #NATALEE #BreastCancer #EarlyBreastCancer #Ribociclib
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Adjuvant ribociclib (RIB) + nonsteroidal aromatase inhibitor (NSAI) in patients (pts) with HR+/HER2− early breast cancer (EBC): NATALEE 6-y overall survival (OS) and efficacy outcomes
https://esmocongress.esmo.org来源：Mirrors of Medicine · x.com