Yakup Ergün· @dr_yakupergun · X·· 22 小时前评分70
正文 · 机器翻译
#ESMO26 | KEYNOTE-B49 – III期
在 PD-L1 CPS ≥1 的 HR+/HER2− mBC 患者中，pembrolizumab + 化疗：
PFS：6.7 vs 6.0 个月（HR 0.74）
OS：21.0 vs 22.2 个月（HR 1.04）
CPS ≥10：PFS HR 0.59；OS HR 0.82。
尽管 PFS 曲线在早期趋于汇合，但在一小部分患者中出现了持久获益的信号。
然而，未显示出 OS 获益，且毒性增加（1.8% G5 TRAE）。
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会议摘要
LBA51按 Proffered paper 2: Breast cancer, early and advanced stage 对上
Results from KEYNOTE-B49: A phase 3, randomized, double-blind study of pembrolizumab (pembro) vs placebo (pbo) plus chemotherapy (CT) in participants (pts) with HR+/HER2− advanced breast cancer (ABC)
https://esmocongress.esmo.org#ESMO26 | KEYNOTE-B49 In patients with PD-L1 CPS ≥1, HR+/HER2− mBC previously treated with ET, pembro + chemo was compared with chemo - PFS: 6.7 vs 6.0 mo (HR 0.74) - OS: 21.0 vs 22.2 mo (HR 1.04) - CPS ≥10: PFS HR 0.59 I’m curious to see the subgroup analyses presented at ESMO. However, in the ADC era, this modest PFS benefit without an OS advantage has little clinical relevance to me. Evaluating immunotherapy in combination with ADCs or after ADC treatment may be more rational in today's treatment landscape.在 X 查看被引用的帖子
来源：Yakup Ergün · x.com