Peking University, Tsinghua and BGI SPAC-seq Spatial CRISPR Screening Method Featured on Cell Cover
A spatial CRISPR screening sequencing technology called SPAC-seq, developed jointly by Peking University, Tsinghua University and BGI, is featured on the cover of Cell. The work includes TARDIS, a statistical framework that links genetic perturbations to spatial phenotypes and the cellular microenvironment, enabling spatially resolved functional genomics research.
Why it matters: SPAC-seq couples CRISPR screening with spatial transcriptomics, and the TARDIS framework lets researchers dissect gene function across tissue locations in situ.