Adding a levonorgestrel IUS to endometrial ablation cuts hysterectomy risk in heavy menstrual bleeding
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The MIRA2 trial, a multicentre, open-label, randomised, controlled, superiority trial conducted in the Netherlands, tested whether combining endometrial ablation with a levonorgestrel-releasing intrauterine system works better than ablation alone for women with heavy menstrual bleeding. The results, published in The Lancet, showed that the combined approach reduced the incidence of hysterectomy compared with ablation alone. The combination also appears to be a safe adjunctive strategy, with no increase in complication risk. The findings support offering the combined treatment to women seeking to avoid hysterectomy, though longer-term follow-up details are not yet covered.
Written by a model from the reports · updated 2 hours ago
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- The LancetPick[Articles] Endometrial ablation plus levonorgestrel-releasing intrauterine system versus endometrial ablation alone in women with heavy menstrual bleeding in The Netherlands (MIRA2): a multicentre, open-label, randomised, controlled, superiority trial
MIRA2, a multicentre, open-label, randomised controlled superiority trial conducted in The Netherlands, showed that endometrial ablation combined with a levonorgestrel-releasing intrauterine system reduced the incidence of hysterectomy in women with heavy menstrual bleeding compared with endometrial ablation alone. The combined treatment appears to be a safe adjunctive strategy that does not increase the risk of complications.
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