Radiation-Driven Collagen Buildup Linked to Immunosuppression in Recurrent Glioblastoma
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A bioRxiv preprint posted on October 21, 2026 reports that repeated irradiation drives accumulation of collagen types I and III in recurrent glioblastoma. In patient samples and mouse models subjected to repeated irradiation, COL I&III expression was upregulated, and higher expression correlated with shorter survival. Spatial transcriptomics showed that COL I&III-enriched regions were accompanied by TGF-β signaling and immunosuppressive cell signatures, suggesting a mechanism by which radiotherapy may reshape the tumor microenvironment toward immune evasion. The findings are based on patient-derived samples and mouse experiments; the work has not yet undergone peer review, and questions such as whether collagen-targeting or TGF-β-pathway interventions can alter outcomes after re-irradiation remain open.
Written by a model from the reports · updated 2 hours ago
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- bioRxivPickRadiation-Induced Collagen I&III Accumulation Drives Immunosuppressive Evolution in Recurrent Glioblastoma
In recurrent glioblastoma patient samples and a repeatedly irradiated mouse model, the study found upregulated COL I&III expression, with high expression associated with shorter survival. Spatial transcriptomics showed that COL I&III-enriched regions are accompanied by TGF-β signaling and immunosuppressive cell signatures.
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