bioRxiv· Iwaloye, O., Barr, L., Takei, J., Tsuzuki, S., Kumar, H., Osuka, S. ·· 1 day agoPickScore57
Radiation-Induced Collagen I&III Accumulation Drives Immunosuppressive Evolution in Recurrent Glioblastoma
In brief
In samples from patients with recurrent glioblastoma and in mouse models of repeated irradiation, the study found upregulated COL I&III expression, with high expression associated with shorter survival. Spatial transcriptomics showed that COL I&III-enriched regions were accompanied by TGF-β signaling and immunosuppressive cell signatures.
Why it matters
Links Collagen I&III accumulation in recurrent glioblastoma to TGF-β signaling and immunosuppression, and suggests synergy between buparlisib and PD-1 blockade in a mouse recurrence model.
Source: bioRxiv