Targeting PLD1 slows growth of chromosome 3q-amplified lung tumors in mice
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A UTHealth Houston team reports in PNAS that non-small cell lung cancer cells with chromosome 3q amplification depend on the enzyme PLD1 to secrete cancer-promoting materials through the Golgi apparatus, the cell's shipping system for proteins. In mice, targeting PLD1 significantly slowed tumor growth without other adverse health effects, pointing to a possible new way to attack this subset of lung cancer. Because chromosome 3q amplification is also common in head and neck cancer and esophageal cancer, the strategy may extend to those tumors as well. The work is at the preclinical stage; translation into human trials has not yet been reported.
Written by a model from the reports · updated 4 hours ago
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- Medical XpressTargeting lung cancer's cellular shipping system could offer a new way to slow tumor growth
A UTHealth Houston team reports in PNAS that non-small cell lung cancer cells with chromosome 3q amplification depend on PLD1 to secrete cancer-promoting materials via the Golgi apparatus. Targeting PLD1 in mice markedly slowed tumor growth without other health damage. Chromosome 3q amplification is also common in head and neck and esophageal cancers, suggesting the strategy may extend to those tumor types. DOI: 10.1073/pnas.2532484123
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