WEE1 phosphorylates CDH1 to promote S phase entry
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A Nature study reports that the kinase WEE1 directly phosphorylates CDH1 at tyrosine residues 91 and 130, inhibiting the APC/C CDH1 ubiquitin ligase complex. This inhibition allows cells to enter S phase promptly after release from quiescence, revealing a mechanism by which WEE1 controls cell cycle progression beyond its established roles. The finding links WEE1 activity to the timing of DNA replication onset. What remains open is how this mechanism operates across other cell states and whether it has implications for targeting WEE1 or APC/C in cancer therapy.
Written by a model from the reports · updated 3 hours ago
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- NaturePickWEE1 opposes APC/C CDH1 activity to promote S phase entry
WEE1 inhibits APC/C CDH1 activity by directly phosphorylating CDH1 at Tyr91 and Tyr130, thereby promoting timely S phase entry after release from quiescence.
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