Nature· Luc-Alban Vuillemenot·· 19 hours agoPickScore80
WEE1 opposes APC/C CDH1 activity to promote S phase entry
In brief
WEE1 inhibits APC/C CDH1 activity by directly phosphorylating CDH1 at Tyr91 and Tyr130, thereby promoting timely S phase entry after release from quiescence.
Why it matters
It reveals a previously unrecognized WEE1 mechanism that explains WEE1 inhibitor clinical toxicity and supports biomarkers such as CDKN1A.
Source: Nature