One-gram wireless mesoscope enables cortex-wide brain imaging in freely moving mice
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A Tsinghua University team has developed Airscope, a 1-gram wireless mesoscope that allows cortex-wide calcium imaging in mice behaving naturally rather than restrained. Alongside the device, the researchers present SAM2Mice, a segmentation method that tracks the identities of multiple animals and supports synchronized group recording. The system was demonstrated across natural behavior paradigms including tube competition, foraging competition, maze exploration, and forced swimming. The team also shows a configuration using two Airscopes to record vascular and neural activity simultaneously in the cortex and spinal cord. The work, published in Nature, expands the range of neural recording tools available for studying brain activity during real social and exploratory behavior.
Written by a model from the reports · updated 3 hours ago
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- NaturePickCortex-wide imaging in naturally behaving mice with 1-gram wireless mesoscopes
A Tsinghua University team developed the Airscope, a 1-gram wireless mesoscope that performs cortex-wide calcium imaging in freely moving mice. An accompanying segmentation method, SAM2Mice, supports multi-animal identity tracking and synchronized group recording, demonstrated across natural behavior paradigms including tube competition, foraging competition, maze exploration and forced swimming. A dual-Airscope setup additionally enables simultaneous imaging of vascular and neural activity in the cortex and spinal cord.
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