Science Study Ties Inherited EGFR T790M Variant to High Lung Cancer Risk
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A study published in Science, led by LoPiccolo and colleagues at Dana-Farber/Harvard Cancer Center in collaboration with the 23andMe Research Team, reports an association between the rare germline EGFR T790M variant and high lung cancer risk. The analysis covered more than 3,300,000 individuals, using variant-level association methods, and also traced the variant's genetic evolution. The findings point to a hereditary route to lung cancer risk in carriers of this variant. Open questions for clinicians include how to translate the risk estimate into screening or preventive guidance for carriers, and whether the variant's evolutionary history informs who carries it and at what age risk emerges.
Written by a model from the reports · updated 3 hours ago
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- mp.weixin.qq.comScience Study with 23andMe Links Germline EGFR T790M to High Lung Cancer Risk
A study published in Science in collaboration with 23andMe reports an association between the rare germline EGFR T790M variant and high lung cancer risk across more than 3,300,000 individuals. LoPiccolo and colleagues at Dana-Farber/Harvard Cancer Center, working with the 23andMe Research Team, conducted variant-level association analyses and reported the variant's genetic evolution.
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