Bailong Xiao Team's In Vivo Screen Identifies Creld1 as Cross-Modal Somatosensory Regulator
Start here
Bailong Xiao's team has built a screening system, published in a Nature journal, that combines postnatal in vivo CRISPR-Cas9 gene editing with somatosensory behavioral assays. Applying it, they identified Creld1 as a regulator that acts across multiple sensory modalities: touch, temperature, pain and itch. The system integrates genome editing with behavioral phenotyping to search for common regulators of different senses, and Creld1 is its first reported find. The work opens a route to systematically uncovering genes that coordinate somatosensation, though further genes and mechanisms the platform may surface, and Creld1's precise role in each modality, have yet to be worked out.
Written by a model from the reports · updated 3 hours ago
Coverage timeline
Follow the coverage to see the different angles.
- mp.weixin.qq.comBailong Xiao Team Builds Behavioral Genomics Screen in Nature Journal, Finds Creld1 Regulates Multiple Somatic Senses
Bailong Xiao's team established a screening system in a Nature journal that combines postnatal in vivo CRISPR–Cas9 gene editing with somatosensory behavioral assays, and identified Creld1 as a cross-modal regulator of touch, temperature, pain and itch. The system integrates genome editing with behavioral phenotyping to screen for common regulators of different sensory modalities.
Heat trend for this story
Heat now 9·Peak in the comparable set 10 (Oct 24 22:00)·Change over 24h in the comparable set –·Participants now 1
Participants counted above, heat below. The trend compares only the participants observed in full throughout, so its set can be smaller than the heat figure itself. Move the pointer or click the chart for an hour's reading; the left and right arrow keys work too.