Spatial epigenomics reveals ancestry-associated regulatory states linked to aggressive prostate cancer biology
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Spatial ATAC-seq analysis of chromatin accessibility in tumors from localized prostate cancer patients receiving equal healthcare access showed reduced accessibility of CTCF-associated motifs in Black patients compared with White patients, along with enrichment of motifs linked to epithelial-mesenchymal transition and inflammation. Downregulated CTCF expression was independently validated by immunohistochemistry in 99 prostatectomy specimens, suggesting ancestry-associated chromatin regulatory differences may contribute to racial disparities in prostate cancer aggressiveness.
Excerpted from bioRxiv
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- bioRxivSpatial epigenomics reveals ancestry-associated regulatory states linked to aggressive prostate cancer biology
Spatial ATAC-seq analysis of chromatin accessibility in tumors from localized prostate cancer patients receiving equal healthcare access showed reduced accessibility of CTCF-associated motifs in Black patients compared with White patients, along with enrichment of motifs linked to epithelial-mesenchymal transition and inflammation. Downregulated CTCF expression was independently validated by immunohistochemistry in 99 prostatectomy specimens, suggesting ancestry-associated chromatin regulatory differences may contribute to racial disparities in prostate cancer aggressiveness.
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