bioRxiv· German Falcon, B., Ho, K.-L., Garbarino, J., Sayed, S., Ali, A., Azadze, W., Truong, T., Elsamanoudi, S., McGann, J., Shrestha, R., Ng, C., Shriver, C. D., Chesnut, G., Ellis, L. ·· 17 hours agoScore41
Spatial epigenomics reveals ancestry-associated regulatory states linked to aggressive prostate cancer biology
In brief
Spatial ATAC-seq analysis of chromatin accessibility in tumors from localized prostate cancer patients receiving equal healthcare access showed reduced accessibility of CTCF-associated motifs in Black patients compared with White patients, along with enrichment of motifs linked to epithelial-mesenchymal transition and inflammation. Downregulated CTCF expression was independently validated by immunohistochemistry in 99 prostatectomy specimens, suggesting ancestry-associated chromatin regulatory differences may contribute to racial disparities in prostate cancer aggressiveness.
Source: bioRxiv