Common CD36 Variant Linked to Dilated Cardiomyopathy Risk in People of African Ancestry
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A multicohort genetic association analysis published in JAMA examined 82,623 individuals of African ancestry to map the genetic landscape of dilated cardiomyopathy. The study found that the CD36 Y325* variant carries a population attributable fraction of 9.0% for dilated cardiomyopathy, exceeding the 3.7% attributed to TTN truncating variants, which are the best-established genetic cause of the disease. The finding positions a common CD36 variant as a larger contributor to disease burden in this population than the classic rare variants in TTN. Questions that remain open include how CD36 Y325* screening might be incorporated into clinical genetic testing and whether the association translates into actionable risk management.
Written by a model from the reports · updated 3 hours ago
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- JAMAPickA Common CD36 Variant and the Genetic Landscape of Dilated Cardiomyopathy in Individuals of African Ancestry.
In a multicohort genetic association analysis of 82,623 individuals of African ancestry, the population attributable fraction of dilated cardiomyopathy for CD36 Y325* was 9.0%, higher than the 3.7% for TTN truncating variants.
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