Breast cancer surgery de-escalation advances as neoadjuvant pCR rates climb
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At SIBCS 2026, Professor Chen Jie of West China Hospital, Sichuan University outlined how breast cancer surgery is being de-escalated as neoadjuvant therapy pushes pathologic complete response rates higher. Studies from Fudan University Shanghai Cancer Center show pCR rates above 80% and even 90%, yet patients with clinical radiologic complete response after neoadjuvant therapy are still considered to require surgery. Chen covered breast-conserving surgery, axillary management, and residual disease assessment. West China's triple-tracer technique for sentinel lymph node mapping showed a false-negative rate of about 2%. Multi-omic approaches to predicting surgical margins remain promising but still need prospective validation before entering practice.
Written by a model from the reports · updated 3 hours ago
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- mp.weixin.qq.comSIBCS 2026: Professor Chen Jie on Advancing and Holding the Line in Breast Cancer Surgery De-escalation in a High-pCR Era
At SIBCS 2026, Professor Chen Jie of West China Hospital, Sichuan University discussed de-escalation pathways in breast cancer surgery amid rising pCR rates, covering breast-conserving surgery, axillary management, and residual disease assessment. She cited Fudan University Shanghai Cancer Center studies showing pCR rates have risen above 80% or even 90%, yet patients with clinical radiologic CR after neoadjuvant therapy are still considered to require surgery. West China's triple-tracer technique showed a false-negative rate of about 2%, while multi-omic margin prediction still needs prospective validation.
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