SIBCS 2026: Professor Chen Jie on Advancing and Holding the Line in Breast Cancer Surgery De-escalation in a High-pCR Era

At SIBCS 2026, Professor Chen Jie of West China Hospital, Sichuan University discussed de-escalation pathways in breast cancer surgery amid rising pCR rates, covering breast-conserving surgery, axillary management, and residual disease assessment. She cited Fudan University Shanghai Cancer Center studies showing pCR rates have risen above 80% or even 90%, yet patients with clinical radiologic CR after neoadjuvant therapy are still considered to require surgery. West China's triple-tracer technique showed a false-negative rate of about 2%, while multi-omic margin prediction still needs prospective validation.