UCSF Team Maps eIF4E mRNA Cap-Binding Pocket With Benzoxaborole Probes
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Researchers at UCSF have used benzoxaborole photoaffinity probes to identify eukaryotic translation initiation factor 4E (eIF4E) in live cells, mapping its binding site to the mRNA cap-binding pocket. The work, published in JACS, provides a chemically precise picture of where this translation initiation factor engages mRNA in its native cellular context. eIF4E is a long-standing point of interest in translation control and cancer biology, and a defined ligand-contact map of the cap-binding pocket may support structure-guided efforts to design small molecules that act on this site. The study establishes the probe approach itself as a way to localize protein-ligand interactions in living cells.
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- mp.weixin.qq.comPickJACS: UCSF Team Uses Benzoxaborole Probes to Pin eIF4E mRNA Cap-Binding Pocket
A UCSF team has published a study in JACS using benzoxaborole photoaffinity probes to identify eukaryotic translation initiation factor 4E (eIF4E) in live cells, and mapped its binding site to the mRNA cap-binding pocket.
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