mp.weixin.qq.com· Candidate·· 18 hours agoPickScore67
JACS: UCSF Team Uses Benzoxaborole Probes to Pin eIF4E mRNA Cap-Binding Pocket
In brief
A UCSF team has published a study in JACS using benzoxaborole photoaffinity probes to identify eukaryotic translation initiation factor 4E (eIF4E) in live cells, and mapped its binding site to the mRNA cap-binding pocket.
Why it matters
Live-cell photoaffinity labeling with chemoproteomics resolves both target and binding pocket of a rare scaffold, offering a transferable method for probe development.
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