New World hantavirus spike structure reveals how it binds human protocadherin-1
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Researchers have resolved the 2.6 Å structure of the intact ANDV Gn–Gc spike bound to human protocadherin-1 (PCDH1), the receptor New World hantaviruses use to enter cells. The structure shows the PCDH1 EC1 domain inserting into a central pocket formed by four Gn molecules, where it contacts four viral glycoproteins simultaneously. The finding, published in Nature, defines the molecular architecture of receptor recognition by these viruses, which cause hantavirus cardiopulmonary syndrome. Open questions include how this four-glycoprotein engagement drives membrane fusion and whether the receptor-binding pocket can be targeted by antivirals or vaccines.
Written by a model from the reports · updated 3 hours ago
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- NaturePickStructural basis for protocadherin-1 recognition by New World hantaviruses
A research team resolved the structure of the complete ANDV Gn–Gc spike bound to human PCDH1 at 2.6 Å resolution. The PCDH1 EC1 domain inserts into a central pocket formed by four Gn molecules and contacts four viral glycoproteins simultaneously.
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