Nature Metabolism Resource Article Maps One-Carbon Metabolism in Cancer Cachexia
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A Resource article published in Nature Metabolism in January 2026 by Morigny, Rohm and colleagues profiles one-carbon metabolism across tissues in cancer cachexia. Working in the C26 mouse model, the researchers analyzed plasma, liver, adipose tissue, heart and skeletal muscle, and their findings point to one-carbon metabolism as a driver of cross-tissue metabolic reprogramming in the cachectic state. The work provides a multi-tissue resource for a syndrome that remains a major unsolved problem in oncology, where muscle and weight loss limit treatment and survival. How the mechanistic leads it generates translate into human cachexia and potential therapeutic targets is still open.
Written by a model from the reports · updated 4 hours ago
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A Resource article published in Nature Metabolism in January 2026, by Morigny, Rohm and colleagues, used the C26 mouse model of cancer cachexia to profile plasma, liver, adipose tissue, heart and skeletal muscle.
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