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Nature Metabolism Resource Article Shows One-Carbon Metabolism Drives Cross-Tissue Metabolic Reprogramming in Cancer Cachexia
In brief
A Resource article published in Nature Metabolism in January 2026, by Morigny, Rohm and colleagues, used the C26 mouse model of cancer cachexia to profile plasma, liver, adipose tissue, heart and skeletal muscle.
Why it matters
Multi-omics tracing shows one-carbon metabolism activated across tissues in six mouse models and human samples, offering a unified mechanism for cachexia.
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