Establishing Polycomb regulatory landscapes in human early development
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The authors profiled H2AK119ub (H2Aub) distribution in human gametes, two-cell embryos, eight-cell embryos, blastocysts and embryonic stem cells, characterizing reprogramming and patterning of this modification during early development. The paper was published in Nature Genetics, doi:10.1038/s41588-026-02764-y, and can serve as a reference for future studies of Polycomb-mediated epigenetic regulation in human early development.
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The authors profiled H2AK119ub (H2Aub) distribution in human gametes, two-cell embryos, eight-cell embryos, blastocysts and embryonic stem cells, characterizing reprogramming and patterning of this modification during early development. The paper was published in Nature Genetics, doi:10.1038/s41588-026-02764-y, and can serve as a reference for future studies of Polycomb-mediated epigenetic regulation in human early development.
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