Cytoplasmic 5hmC signal reveals RNA hydroxymethylation in breast cancer
Start here
A bioRxiv preprint by Wen et al. reports a quantifiable cytoplasmic 5-hydroxymethylcytosine (5hmC) signal in breast cancer cell lines and human breast cancer tissue. The signal was confirmed with an RNase-sensitive, RNA-specific ELISA and reflects hydroxymethylation of total RNA and mRNA rather than DNA. The mark is enriched in triple-negative (ER-/PR-/HER2-) breast cancer and in grade 3 tumors, and correlates with increased cytoplasmic TET2 and TET3, implicating these enzymes in cytoplasmic RNA modification. The findings are published as a preprint and have not yet undergone peer review, and the functional consequences of RNA hydroxymethylation for tumor biology remain open questions.
Written by a model from the reports · updated 3 hours ago
Coverage timeline
Follow the coverage to see the different angles.
- bioRxivPickCytoplasmic localization of 5hmC reveals RNA hydroxymethylation in breast cancer
Wen et al. report in a bioRxiv preprint a quantifiable cytoplasmic 5hmC signal in breast cancer cell lines and human breast cancer tissue. Confirmed by an RNase-sensitive, RNA-specific ELISA, the signal reflects hydroxymethylation of total RNA and mRNA, and is enriched in triple-negative (ER-/PR-/HER2-) breast cancer and grade 3 tumors, correlating with increased cytoplasmic TET2/TET3.
Coverage and heat for this story
Reports so far 1·Heat now 5·Peak heat 10 (Oct 21 08:00)·Reports, 24h 0
Two panels, same clock (pointer stays in sync): top is cumulative editorial reports — only rises; last point = All reports; slope = new reports that hour. Bottom is Live-board heatIndex — 7-day participants with a 24-hour half-life, so it can fall when talk cools.