Surface Y RNA on Monocytes Amplifies Inflammatory Signaling, Study Finds
Start here
A team led by Hu Lulu has discovered that Y RNA sitting on the surface of human monocytes captures extracellular histones released by tissue damage. This promotes the interaction of those histones with TLR2/TLR4-associated signaling pathways and amplifies innate immune inflammatory responses. Published in Nature Cell Biology, the work used a method called HASTE to dissect cell-surface RNA function, alongside clinical cohort analyses and animal experiments. The findings suggest surface Y RNA could serve as an auxiliary biomarker for inflammatory bowel disease and as a potential target for intervention. Follow-up work to translate the discovery into clinical biomarker or therapeutic applications remains to be done.
Written by a model from the reports · updated 4 hours ago
Coverage timeline
Follow the coverage to see the different angles.
- mp.weixin.qq.comHu Lulu Team Finds Surface Y RNA on Human Monocytes Amplifies Innate Immune Inflammatory Signaling
A study by Hu Lulu's team published in Nature Cell Biology shows that Y RNA on the surface of human monocytes captures extracellular histones released by tissue damage, promoting their interaction with TLR2/TLR4-associated signaling pathways and amplifying inflammatory responses. Using HASTE to dissect cell-surface RNA function, clinical cohort analyses and animal experiments suggest surface Y RNA could serve as an auxiliary biomarker and potential intervention target for inflammatory bowel disease.
Heat trend for this story
Heat now 7·Peak in the comparable set 10 (Oct 23 17:00)·Change over 24h in the comparable set –·Participants now 1
Participants counted above, heat below. The trend compares only the participants observed in full throughout, so its set can be smaller than the heat figure itself. Move the pointer or click the chart for an hour's reading; the left and right arrow keys work too.