Blocking mitochondrial enzyme CA-VB protects brain vessels and memory in Alzheimer's models
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A study published in Science Advances reports that inhibiting mitochondrial carbonic anhydrase CA-VB counteracts cerebrovascular damage driven by amyloid-beta. In human brain microvascular endothelial cells, CA-VB inhibition prevented mitochondria-mediated endothelial apoptosis, loss of barrier resistance and inflammatory activation. In 3xTg Alzheimer's disease mice, the same approach reduced caspase activation and endothelial activation in the brain and preserved memory. The findings position CA-VB as a potential therapeutic target against the cerebrovascular pathology and cognitive impairment associated with Alzheimer's disease. Whether the effect translates to human disease remains untested, as all evidence so far comes from cell and mouse models.
Written by a model from the reports · updated 3 hours ago
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- Science AdvancesMitochondrial carbonic anhydrase-VB inhibition rescues brain endothelial stress and memory in Alzheimer's disease models.
Inhibiting mitochondrial carbonic anhydrase CA-VB prevents Aβ-induced mitochondria-mediated endothelial apoptosis, loss of barrier resistance, and inflammatory activation in hCMEC cells and 3xTg Alzheimer's disease mice. CA-V inhibition also reduces caspase activation and endothelial activation in the brains of 3xTg mice and preserves memory, pointing to this target as a potential intervention against AD cerebrovascular pathology and cognitive impairment.
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