Human gene BC200 found able to jump, twice inserting itself into a poxvirus
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A Cornell University team reports in Science that BC200, a human gene expressed mainly in neurons, has retained the ability to transpose. The gene inserted itself twice into the genome of molluscum contagiosum virus, a poxvirus. BC200 is thought to regulate messenger RNA translation, and its abnormal expression has been observed in some tumors and in the brains of Alzheimer's patients. The transposition mechanism and any functional consequences of the insertions have not yet been characterized, and the gene's links to cancer and neurodegeneration remain open questions for future research.
Written by a model from the reports · updated 3 hours ago
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- news.bioon.comScience paper shows human gene BC200 can transpose and twice inserted into a poxvirus
A Cornell University team reports in Science that the human gene BC200 has retained the ability to move and twice inserted itself into the molluscum contagiosum virus (MCV) genome. BC200 is expressed mainly in neurons, and evidence suggests it may regulate messenger RNA translation; its abnormal expression in some tumors and in the brains of Alzheimer's patients remains a focus for future research. DOI: 10.1126/science.aeh3441.
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