Blocking microglia-released LPA signals may curb glioblastoma invasion, study finds
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A research team at VIB-KU Leuven has published a study in Cancer Cell showing that lysophosphatidic acids (LPAs) released by microglia promote the invasion of glioblastoma cells into healthy brain tissue. In experiments, blocking this signaling reduced the invasiveness of the tumor cells, though it did not shrink the tumor itself. The findings suggest the LPA pathway as a potential target for making glioblastoma less invasive, which could in principle ease surgical removal, but the work is at the preclinical stage and has not yet produced a therapy tested in patients.
Written by a model from the reports · updated 4 hours ago
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A VIB-KU Leuven team publishing in Cancer Cell found that lysophosphatidic acids (LPAs) released by microglia promote invasion of glioblastoma cells into healthy brain tissue. Blocking this signaling reduced invasiveness but did not shrink the tumor.
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