Generative design yields enantioselective artificial metalloenzyme photocatalysts
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Researchers led by Sandip Mishra report in Nature the de novo design of artificial metalloenzymes that combine generative protein design with directed evolution. The proteins selectively bind metal polypyridyl photocatalysts and support a range of light-driven reactions. The evolved enzymes achieve high catalytic turnover and can be recycled, and they work with commercially available racemic metal complexes, avoiding the need for bespoke chiral catalysts. The work demonstrates a route to enzymes whose selectivity is programmed by design rather than found in nature.
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- NaturePickDe novo design of enantioselective artificial metalloenzyme photocatalysts
Sandip Mishra and colleagues report in Nature that generative protein design and directed evolution produced a highly enantioselective artificial metalloenzyme that selectively binds a metal polypyridyl photocatalyst. The evolved proteins support diverse light-driven reactions, achieve high catalytic turnover and catalyst recycling, and work with commercially available racemic metal complexes.
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