The pyrin inflammasome senses OCTN2-mediated uptake of extracellular ʟ-carnitine from muscle injury or ingestion
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A study finds that the pyrin inflammasome senses extracellular L-carnitine through the high-affinity carnitine transporter OCTN2 (SLC22A5), triggering IL-1β-mediated inflammation. Both muscle injury and ingestion of L-carnitine-rich muscle tissue raise extracellular L-carnitine, and the authors propose OCTN2 as a potential target for reducing such inflammation.
Excerpted from Cell
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- CellPickThe pyrin inflammasome senses OCTN2-mediated uptake of extracellular ʟ-carnitine from muscle injury or ingestion
A study finds that the pyrin inflammasome senses extracellular L-carnitine through the high-affinity carnitine transporter OCTN2 (SLC22A5), triggering IL-1β-mediated inflammation. Both muscle injury and ingestion of L-carnitine-rich muscle tissue raise extracellular L-carnitine, and the authors propose OCTN2 as a potential target for reducing such inflammation.
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