Cell· Eric I. Elliott, Tomomi M. Yoshida, Susana C.B.R. Nakandakari, Scott Pope, Cuiling Zhang, Timothy Nottoli, Jae Jin Chae, Daniel L. Kastner, Richard A. Flavell, Vishwa Deep Dixit, Vijay A. Rathinam, Fayyaz S. Sutterwala, Andrew Wang·· 18 hours agoPickScore72
The pyrin inflammasome senses OCTN2-mediated uptake of extracellular ʟ-carnitine from muscle injury or ingestion
In brief
A study finds that the pyrin inflammasome senses extracellular L-carnitine through the high-affinity carnitine transporter OCTN2 (SLC22A5), triggering IL-1β-mediated inflammation. Both muscle injury and ingestion of L-carnitine-rich muscle tissue raise extracellular L-carnitine, and the authors propose OCTN2 as a potential target for reducing such inflammation.
Why it matters
The paper links OCTN2 transport to pyrin inflammasome activation, suggesting OCTN2 as a potential target to suppress inflammation from exogenous or endogenous L-carnitine.
Source: Cell