Genome-wide study finds 60 loci tied to liver triglyceride content
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A genome-wide association analysis of 71,488 UK Biobank participants has identified 60 independent loci associated with liver triglyceride content, a marker of fatty liver disease. Published in Nature Genetics, the study goes beyond mapping: polygenic scores constructed from these loci were linked to elevated risk of cirrhosis and hepatocellular carcinoma, suggesting inherited susceptibility to fat accumulation in the liver may help stratify patients at risk of progressive liver disease. The findings establish a genetic foundation for studying hepatic triglyceride metabolism, though clinical application of the risk scores and the biological mechanisms at individual loci have yet to be worked out.
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- NatureGenome-wide analyses identify 60 loci associated with liver triglyceride content
A genome-wide association analysis of 71,488 UK Biobank participants identified 60 independent loci associated with liver triglyceride content. Polygenic scores built from these loci were associated with elevated risk of cirrhosis and hepatocellular carcinoma. The study was published in Nature Genetics, doi:10.1038/s41588-026-02794-6.
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