Hemispheric Asymmetry in Alzheimer's Biomarkers Linked to Cognitive Decline Patterns
Start here
A study of 585 patients with early-onset Alzheimer's disease across two cohorts examined hemispheric asymmetry in amyloid PET, tau PET, and cortical atrophy measured by MRI. Asymmetry proved common and was associated with cognitive deficits and neuropsychiatric symptoms that depended on which hemisphere was more affected. Longitudinal analyses showed that amyloid PET asymmetry remained stable over time, tau PET asymmetry decreased, and MRI volume asymmetry increased, suggesting a time-lagged sequence in which amyloid, tau, and atrophy abnormalities peak in succession. The findings, published in Annals of Neurology, point to asymmetric disease progression as a meaningful feature of early-onset Alzheimer's, though the mechanisms driving the hemisphere-dependent trajectories remain unexplained.
Written by a model from the reports · updated 4 hours ago
Coverage timeline
Follow the coverage to see the different angles.
- Ann NeurolPickHemispheric Asymmetry of Neuroimaging Biomarkers in Early Onset Alzheimer's Disease: Clinical and Cognitive Outcomes.
A study of 585 patients with early-onset Alzheimer's disease across two cohorts found that hemispheric asymmetry in amyloid PET, tau PET, and cortical atrophy is common and correlates with hemisphere-dependent cognitive deficits and neuropsychiatric symptoms. Longitudinal analyses showed stable amyloid PET asymmetry, decreasing tau PET asymmetry, and increasing MRI volume asymmetry, suggesting a time-lagged peak pattern from amyloid to tau to atrophy.
Coverage and heat for this story
Reports so far 1·Heat now 9·Peak heat 10 (Oct 20 21:00)·Reports, 24h +1
Two panels, same clock (pointer stays in sync): top is cumulative editorial reports — only rises; last point = All reports; slope = new reports that hour. Bottom is Live-board heatIndex — 7-day participants with a 24-hour half-life, so it can fall when talk cools.