Osaka University team identifies neutrophil-epithelial niche driving ANCA kidney injury
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Researchers at Osaka University used spatial transcriptomics on kidney tissue from untreated ANCA-associated glomerulonephritis patients to identify an early neutrophil-epithelial niche involved in the disease. In a mouse model, a modified antibody designed to reduce Fcγ receptor stimulation lessened kidney injury. The findings, published in the Journal of Experimental Medicine, point to curbing the early neutrophil surge as a potential treatment strategy for autoimmune diseases. The work is preclinical on the antibody side, and translation to patients has not yet been demonstrated.
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- Medical XpressPickCurbing the neutrophil surge: New treatment offers hope for autoimmune diseases
Researchers at the University of Osaka report in the Journal of Experimental Medicine that spatial transcriptomics identified early neutrophil-epithelial niches in kidney tissue from untreated ANCA-associated glomerulonephritis patients. In a mouse model, modified antibodies that reduce Fcγ receptor stimulation lessened kidney injury. DOI: 10.1084/jem.20260506.
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