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Changes to H-1B visa fees and selection rules are pushing U.S. biopharmas to cut overseas hiring and turn to candidates already authorized to work in the United States. USCIS announced in May that properly submitted registrations fell 38.5%, from 343,981 in fiscal year 2026 to 211,600 in fiscal year 2027. Two federal judges have separately blocked the $100,000 new-petition fee, but companies had already reduced lottery participation over cost concerns.
Excerpted from biospace.com
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- biospace.comPickAs H-1B visa changes keep coming, biopharmas adjust hiring approach
Changes to H-1B visa fees and selection rules are pushing U.S. biopharmas to cut overseas hiring and turn to candidates already authorized to work in the United States. USCIS announced in May that properly submitted registrations fell 38.5%, from 343,981 in fiscal year 2026 to 211,600 in fiscal year 2027. Two federal judges have separately blocked the $100,000 new-petition fee, but companies had already reduced lottery participation over cost concerns.
- biorxiv.orgResponseVerdict overturns computationally validated immunotherapy signatures, recovers their missed responders and outperforms every published response predictor
ResponseVerdict reorients immunotherapy response signatures using measured responses in other treated cohorts. Across 2,045 patients it raises AUROC by 0.14 over TIDE, and in 2,000 paired comparisons it is significantly better than published predictors in 1,178 of them.
- biospace.comReport: Biopharma Job Market Report Q3 2026
- prnewswire.comImmunic Appoints Jaa Roberson as Chief People Officer
Immunic appointed Jaa Roberson as Chief People Officer, effective the same day; she reports to CEO Erik Lundgren and joins the executive leadership team. She will lead global talent and organizational strategy to prepare the organization for the Phase 3 ENSURE read-out expected by the end of 2026 and for potential regulatory filings and commercialization of vidofludimus calcium (IMU-838).
- nature.comDaily briefing: China’s extraordinary rise in science
In less than 50 years, China has gone from having almost no international scientific presence to a research powerhouse on course to lead global R&D. The trend of AI graduates staying in the country and the rise of DeepSeek and MoonshotAI are helping it catch up with the United States, but research misconduct and ethics controversies remain systemic problems. Nature's daily briefing also covers Eli Lilly presenting early clinical results of a tirzepatide-related compound for alcohol use disorder, and the discovery in Turkey of what may be the oldest shipwreck found to date.
- biorxiv.orgPickGlyceraldehyde-3-phosphate sensing by SOS1 and RAS sustains a self-reinforcing oncogenic metabolic-signaling circuit
The glycolytic intermediate glyceraldehyde-3-phosphate (GA3P) directly binds SOS1 and RAS, enhancing their interaction and sustaining hyperactivated RAS signaling in RAS-mutant cancer cells. GA3P accumulates through MAZ-dependent transcriptional upregulation of GLUT6, an atypical class III glucose transporter. Suppressing MAZ or GLUT6 selectively inhibits RAS-mutant cancer cells in vitro and in vivo, and GLUT6 expression is elevated in clinical RAS-mutant human malignancies.
- nature.comDaily briefing: Visit a huge climate experiment in the Amazon rainforest
Nature's daily briefing on the 12th leads with AmazonFACE, a huge climate experiment in the Amazon rainforest. The project will launch in the coming months and spend a decade testing whether elevated atmospheric CO2 can boost plant growth and sequester carbon. Other topics include tattoo ink revealed by ultraviolet light, a US proposal to charge a $100,000 OPT fee for international graduates, an IPCC deadlock over timelines, and uneven PhD pay across Europe.
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Heat now 78·Peak in the comparable set 168 (Oct 24 03:00)·Change over 24h in the comparable set -40%·Participants now 28
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