Cell adhesion integrity activates mechanosensitive proliferative signaling
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New experiments in MCF10A cells show that adhesion integrity is not just structural scaffolding but an active driver of proliferation. Adhesion maintained by P-cadherin and FAK enhances Src-dependent activation of myosin II and ERK, and strengthens ERK and SRF signaling to support cell proliferation. The work maps a mechanosensitive pathway linking cell-substrate attachment to transcriptional programs governing growth. The findings currently rest on in vitro evidence in a single cell model, and whether the same signaling axis operates in tissues and tumors in vivo remains an open question.
Written by a model from the reports · updated 3 hours ago
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- doi.orgPickAdhesion integrity activates mechanosensitive proliferative signaling
Experiments in MCF10A cells show that adhesion integrity maintained by P-cadherin and FAK enhances Src-dependent myosin II and ERK activation, and strengthens ERK and SRF signaling to support cell proliferation.
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