Neuron study maps multi-omics of 85 familial dementia iPSC lines, revealing cellular heterogeneity and regulators of organoid development
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The Geschwind group at UCLA and the Temple group at the New York Neural Stem Cell Institute published a resource paper in Neuron on October 14, 2026, characterizing 85 familial dementia iPSC lines carrying MAPT mutations and their isogenic controls with WGS, long-read sequencing, single-cell transcriptomics, and DNA methylation profiling. Qi Le and Taylor Bertucci are co-first authors.
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The Geschwind group at UCLA and the Temple group at the New York Neural Stem Cell Institute published a resource paper in Neuron on October 14, 2026, characterizing 85 familial dementia iPSC lines carrying MAPT mutations and their isogenic controls with WGS, long-read sequencing, single-cell transcriptomics, and DNA methylation profiling. Qi Le and Taylor Bertucci are co-first authors.
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