Neuron study maps multi-omics of 85 familial dementia iPSC lines, revealing cellular heterogeneity and regulators of organoid development

The Geschwind group at UCLA and the Temple group at the New York Neural Stem Cell Institute published a resource paper in Neuron on October 14, 2026, characterizing 85 familial dementia iPSC lines carrying MAPT mutations and their isogenic controls with WGS, long-read sequencing, single-cell transcriptomics, and DNA methylation profiling. Qi Le and Taylor Bertucci are co-first authors.