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DP20CQ niosomes, built with DOTMA and polysorbate 20 plus chloroquine, delivered genes more effectively than DP80CH formulations in Palbociclib-induced senescent UC-MSCs from four donors. At DOTMA/DNA ratios of 10/1 and 15/1, DP20CQ achieved the highest transgene expression in senescent UC-MSCs, surpassing Lipofectamine, with strong endosomal escape at 10/1 and no loss of cell viability. This positions niosomes as gene delivery vehicles for senescent cells in antiaging therapy.
Excerpted from doi.org
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- doi.orgInnovative niosome screening for efficient gene delivery in senescent primary umbilical cord stroma-derived MSCs
DP20CQ niosomes, built with DOTMA and polysorbate 20 plus chloroquine, delivered genes more effectively than DP80CH formulations in Palbociclib-induced senescent UC-MSCs from four donors. At DOTMA/DNA ratios of 10/1 and 15/1, DP20CQ achieved the highest transgene expression in senescent UC-MSCs, surpassing Lipofectamine, with strong endosomal escape at 10/1 and no loss of cell viability. This positions niosomes as gene delivery vehicles for senescent cells in antiaging therapy.
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Heat now 31·Peak in the comparable set 37 (Oct 25 06:00)·Change over 24h in the comparable set +185%·Participants now 6
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