Multiancestry COJO method sharpens genetic association mapping from GWAS summary statistics
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Researchers have published Manc-COJO, a multiancestry conditional and joint analysis method for genome-wide association study (GWAS) summary statistics, in Nature Genetics on 20 October 2026. The method integrates data from multiple ancestries to identify independent genetic associations, aiming to reduce the false positives that arise in single-ancestry analyses. It is designed to support fast and flexible conditional and joint analysis across diverse populations. The paper is available online under DOI 10.1038/s41588-026-02799-1. Application of the method to new datasets and comparison with existing single-ancestry approaches remain open questions for future work.
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Manc-COJO is a multiancestry conditional and joint analysis method for GWAS summary statistics. It integrates data from multiple ancestries to identify independent genetic associations, reduces false positives from single-ancestry analysis, and supports fast, flexible conditional and joint analysis across diverse populations. The paper was published online in Nature Genetics on 20 October 2026, DOI: 10.1038/s41588-026-02799-1.
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