Cell· Jack Bryant, Laura Herron, Yesh Doctor, Finn McRae, Jocelyn Wang, Theodore Hirsch, Andrew Portell, Satheesh Kumar, Prashant Mali·· 18 hours agoPickScore69
Regulatable in vivo gene expression via adaptamers
In brief
Bryant et al. developed compact RNA switches called adaptamers that harness endogenous RNA editing to regulate gene expression, activated by an FDA-approved drug and requiring no foreign proteins. In mice, controllable expression of a metabolic hormone reversed obesity, offering a simpler route to drug-controlled gene therapy.
Why it matters
The paper presents the mouse obesity reversal results, showing whether this in vivo regulation approach works, useful reference for teams pursuing drug-controlled gene therapy.
Source: Cell